uthymic Patients with Bipolar Disorder Show ecreased Reward Learning in a Probabilistic eward Task

نویسندگان

  • iego A. Pizzagalli
  • Elena Goetz
  • Michael Ostacher
  • Dan V. Iosifescu
  • Roy H. Perlis
چکیده

ackground: Bipolar disorder (BPD) features cycling mood states ranging from depression to mania with intermittent phases of euthymia. ipolar disorder subjects often show excessive goal-directed and pleasure-seeking behavior during manic episodes and reduced hedonic apacity during depressive episodes, indicating that BPD might involve altered reward processing. Our goal was to test the hypothesis that PD is characterized by impairments in adjusting behavior as a function of prior reinforcement history, particularly in the presence of esidual anhedonic symptoms.

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تاریخ انتشار 2008